Transmission intensity and human immune responses to lymphatic filariasis.
Identifieur interne : 009957 ( Main/Exploration ); précédent : 009956; suivant : 009958Transmission intensity and human immune responses to lymphatic filariasis.
Auteurs : C L King [États-Unis]Source :
- Parasite immunology [ 0141-9838 ] ; 2001.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Animaux, Anticorps antihelminthe (immunologie), Antigènes d'helminthe (immunologie), Brugia malayi (immunologie), Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Filariose lymphatique (transmission), Granulocytes basophiles (immunologie), Humains, Hypersensibilité immédiate, Lymphocytes auxiliaires Th2 (immunologie), Wuchereria bancrofti (croissance et développement), Wuchereria bancrofti (immunologie).
- MESH :
- croissance et développement : Wuchereria bancrofti.
- immunologie : Anticorps antihelminthe, Antigènes d'helminthe, Brugia malayi, Filariose lymphatique, Granulocytes basophiles, Lymphocytes auxiliaires Th2, Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- transmission : Activation des lymphocytes, Animaux, Filariose lymphatique, Humains, Hypersensibilité immédiate.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (immunology), Antigens, Helminth (immunology), Basophils (immunology), Brugia malayi (immunology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (transmission), Humans, Hypersensitivity, Immediate, Lymphocyte Activation, Th2 Cells (immunology), Wuchereria bancrofti (growth & development), Wuchereria bancrofti (immunology).
- MESH :
- chemical , immunology : Antibodies, Helminth, Antigens, Helminth.
- growth & development : Wuchereria bancrofti.
- immunology : Basophils, Brugia malayi, Elephantiasis, Filarial, Th2 Cells, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- transmission : Elephantiasis, Filarial.
- Animals, Humans, Hypersensitivity, Immediate, Lymphocyte Activation.
Abstract
Our understanding of how the host immune response influences the risk of developing disease has changed dramatically over the past decade. Previously, the spectrum of disease associated with lymphatic filariasis was largely attributed to the nature of the host immune response. Now, we appreciate that the duration and intensity of infection and possibly the direct influence of parasite-derived molecules also determine the risk of disease. Individuals chronically infected with lymphatic filariasis generally have an impaired lymphocyte proliferation response to filarial antigens and favour Th2-type cytokine responses. This ability to down-modulate the host immune response may help protect the host from disease. Defects in antigen-presenting cell (APC) function appear to participate in this acquired immune hyporesponsiveness, although the mechanisms as to how this occurs are poorly understood. Here, we present evidence that repeated exposure to infective stage larvae and their secreted products may stimulate basophils and mast cells to related products that may impair APC function.
PubMed: 11472556
Affiliations:
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Le document en format XML
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sortKey="King, C L" sort="King, C L" uniqKey="King C" first="C L" last="King">C L King</name><affiliation wicri:level="2"><nlm:affiliation>Division of Geographic Medicine, Case Western Reserve University School of Medicine and Veteran Affairs Medical Center, Cleveland, OH 44106-4983, USA. cxk21@po.cwru.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Geographic Medicine, Case Western Reserve University School of Medicine and Veteran Affairs Medical Center, Cleveland, OH 44106-4983</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author></analytic><series><title level="j">Parasite immunology</title><idno type="ISSN">0141-9838</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (immunology)</term><term>Antigens, Helminth (immunology)</term><term>Basophils (immunology)</term><term>Brugia malayi (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Elephantiasis, Filarial (transmission)</term><term>Humans</term><term>Hypersensitivity, Immediate</term><term>Lymphocyte Activation</term><term>Th2 Cells (immunology)</term><term>Wuchereria bancrofti (growth & development)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term><term>Animaux</term><term>Anticorps antihelminthe (immunologie)</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia malayi (immunologie)</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (transmission)</term><term>Granulocytes basophiles (immunologie)</term><term>Humains</term><term>Hypersensibilité immédiate</term><term>Lymphocytes auxiliaires Th2 (immunologie)</term><term>Wuchereria bancrofti (croissance et développement)</term><term>Wuchereria bancrofti (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Helminth</term><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Antigènes d'helminthe</term><term>Brugia malayi</term><term>Filariose lymphatique</term><term>Granulocytes basophiles</term><term>Lymphocytes auxiliaires Th2</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Basophils</term><term>Brugia malayi</term><term>Elephantiasis, Filarial</term><term>Th2 Cells</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Hypersensitivity, Immediate</term><term>Lymphocyte Activation</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="fr"><term>Activation des lymphocytes</term><term>Animaux</term><term>Filariose lymphatique</term><term>Humains</term><term>Hypersensibilité immédiate</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Our understanding of how the host immune response influences the risk of developing disease has changed dramatically over the past decade. Previously, the spectrum of disease associated with lymphatic filariasis was largely attributed to the nature of the host immune response. Now, we appreciate that the duration and intensity of infection and possibly the direct influence of parasite-derived molecules also determine the risk of disease. Individuals chronically infected with lymphatic filariasis generally have an impaired lymphocyte proliferation response to filarial antigens and favour Th2-type cytokine responses. This ability to down-modulate the host immune response may help protect the host from disease. Defects in antigen-presenting cell (APC) function appear to participate in this acquired immune hyporesponsiveness, although the mechanisms as to how this occurs are poorly understood. Here, we present evidence that repeated exposure to infective stage larvae and their secreted products may stimulate basophils and mast cells to related products that may impair APC function.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="King, C L" sort="King, C L" uniqKey="King C" first="C L" last="King">C L King</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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